在体外培养vivax类型的疟疾寄生虫Plasmodium cynomolgi的培养
Science (New York, N.Y.)
|June 5, 1981
概括
一种猿类疟疾寄生虫Plasmodium cynomolgi在体外成功培养了6周. 培养的寄生虫仍然对子具有传染性,并且显示了可逆的变化在虫的行为.
科学领域:
- * 寄生虫学 寄生虫学
- * 传染病 传染病
- * 疟疾研究
背景情况:
- *Plasmodium cynomolgi是一种活体类型的猿类疟疾寄生虫.
- *体外培养方法对于研究疟疾寄生虫至关重要.
研究的目的:
- * 建立和评估用于Plasmodium cynomolgi.gi的体外培养技术.
- * 评估培养寄生虫的传染性和特征.
主要方法:
- *使用瓶方法和连续流技术培养了Plasmodium cynomolgi.
- *利用 rhesus的红细胞和 RPMI 1640介质与疹缓冲剂和人类血清.
- * 维持培养六周.
主要成果:
- *在六周后,获得了原始注射剂的累积稀释5 X 10 ((6)).
- *培养的寄生虫对 rhesus 子仍然具有传染性.
- * 观测到热石的阿米形行为有可逆性的下降.
结论:
- *使用已确定的方法,可以成功地在体外培养Plasmodium cynomolgi.
- *培养的寄生虫保留了传染性,并表现出改变的,但可逆的形态特征.
- * 这项研究为进一步研究Plasmodium cynomolgi生物学和控制提供了基础.
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