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血清素对感觉运动反应的兴奋和抑制作用,用声学惊测量

M Davis, D I Strachan, E Kass

Science (New York, N.Y.)

|July 25, 1980

概括

氨酸会根据它的位置不同地影响声学惊反射. 在老鼠中,中枢神经系统的管理减少了惊,而脊髓的管理增加了它.

科学领域:

神经科学是一个神经科学.
行为神经科学行为神经科学
神经药理学神经药理学

背景情况:

神经递质血清素在调节各种生理和行为过程中起着至关重要的作用.
了解血清素在中枢神经系统不同区域的不同作用,对于理解其复杂功能至关重要.

研究的目的:

为了研究血清素对大鼠声学惊反射的相反作用.
确定中枢神经系统内血清的管理位置如何影响其对特定行为的影响.

主要方法:

将血清素注入老鼠大脑的侧心室.
在大鼠的脊髓中注射血清.
在注入血清后对声学惊反射的剂量依赖性评估.

主要成果:

将血清注入侧心室导致声学惊反射的剂量依赖性下降.
将血清注入脊髓导致声学惊反射的剂量依赖性增加.
证明了血清素对同一行为反应的对立调节效应.

结论:

血清激素对声学惊反射表现出特定区域的调节效应.
中枢神经系统对的反应取决于涉及的特定神经通路.
强调神经递质在行为控制中的复杂和上下文依赖的作用.

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