多重免疫复合体和在皮肤炎形性皮肤炎和心脏病中出现的低补充血
Lancet (London, England)
|September 4, 1976
概括
循环免疫复合体存在于所有皮肤炎形 (D.H.) 和腹腔疾病 (C.D.) 中. 患者. 患者. 患者. 这些复合体不同于系统性红斑狼 (SLEE) 的复合体. ) 可能解释各种组织损伤.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 皮肤病学 皮肤病学
背景情况:
- 循环免疫复合体 (CICs) 与自身免疫和炎症疾病有关.
- 皮肤炎形 (D.H.) 和腹腔疾病 (C.D.) 是具有重叠免疫学特征的不同疾病.
研究的目的:
- 调查患有D.H.和C.D.的患者中CIC的存在和特征.
- 为了比较 DH 和 CD 中的 CIC. 与在全身性红斑狼 (SLEE) 中发现的那些. ) 的情况.
主要方法:
- 使用放射生物测试,C1q结合活性和聚乙烯糖醇沉检测CIC.
- 在患者血清中对补充成分 (C3和C4) 的分析.
- 在DH,CD和SLE之间比较CIC配置文件. 队伍. 队伍. 在队伍.
主要成果:
- 百分之百的D.H.和CD. 在多种检测方法中,患者表现出CIC.
- 在DH和CD中的CIC. 显示了各种各样的特性,与SLE的一致配置不同.
- 低补充血 (低C3或C4) 观察到在显著比例的D.H.和CD. 患者. 患者. 患者.
结论:
- 在DH和CD中存在各种CIC的存在. 与S.L.E.相比,这表明与S.L.E.相比,有一个不同的免疫病理机制.
- 这些异质免疫复合体可能会导致在DH和CD的皮肤和肠道中观察到的特定组织损伤. 患者. 患者. 患者.
- 补体系统异常与D.H.和C.D.有关,需要进一步调查.
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