自然杀手细胞的神秘之处
1Department of Structural Biology and Microbiology, Stanford University, California 94305, USA.
Nature
|November 16, 1995
概括
自然杀手 (NK) 细胞使用受体来识别主要组织相容性复合体 (MHC) I 类分子. 人类和小鼠NK细胞受体的差异表明适应多样化和进化的MHC配体.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
背景情况:
- 自然杀手 (NK) 细胞对于天生的免疫力至关重要.
- NK细胞的活性由与主要基因相容性复合体 (MHC) I 类分子结合的受体调节.
- 细胞毒性T淋巴细胞 (CTLs) 也利用MHC I类的受体,补充免疫反应.
研究的目的:
- 为了比较NK细胞受体对人类和小鼠MHCI类分子的结构性质.
- 在免疫反应的背景下,了解这些差异的进化含义.
主要方法:
- 已知NK细胞受体结构的比较分析.
- 关于NK细胞和CTL受体功能的文献综述.
- 根据MHC连接体的进化压力推断.
主要成果:
- 人类NK细胞受体结合MHC I类具有免疫球蛋白域.
- 鼠NK细胞受体结合MHC I类表现出C型学菌素域.
- 这些结构差异与MHC I类连接体的多样性和快速演变性相关.
结论:
- 人类和小鼠NK细胞受体的独特结构反映了不同的进化路径.
- 这些适应可能是由需要识别广泛的多态MHC I类分子驱动的.
- 了解这些受体-连接体相互作用是理解对病原体和癌症的免疫监测的关键.
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相关概念视频
Cell-mediated Immune Responses
Overview
Cells of the Innate Immune Response
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Immune Surveillance by NK Cells and Phagocytes
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Antigens Involved in Adaptive Immunity
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Cytotoxic T Cells-mediated Immune Response
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immune Response Against Viral Pathogens
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
