部分激活CD8+ T细胞由自衍生的部分激活
1Beirne B. Carter Center for Immunology Research, University of Virginia Health Sciences Center, Charlottesville 22908, USA.
Nature
|November 16, 1995
概括
主要基因相容性复合体 (MHC) 分子所呈现的的结构变化可以选择性地触发CD95-CD95L介导的CD8+T细胞杀死,独立于穿孔素通路.
科学领域:
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
背景情况:
- T细胞激活通常需要由主要基因相容性复合体 (MHC) 分子呈现特定的.
- 免疫性的结构变异可以调节T细胞反应,包括部分激活或对抗.
- CD8+ T细胞利用孔素依赖的颗粒细胞外和CD95-CD95L相互作用用于化细胞.
研究的目的:
- 研究CD8+ T细胞在被结构相似的刺激时的差异性杀死机制.
- 为了确定CD95-CD95L介导的杀死是否可以独立于穿孔素通路触发.
- 探索MHC结合中微小结构变化的对T细胞细胞毒性的影响.
主要方法:
- 使用了一种针对流感血素的Kd受限CD8+T细胞克隆.
- 刺激的T细胞与骨髓瘤瘤免疫球蛋白重链可变区域 (IgVH) 及其生殖系对应物.
- 在不同的刺激条件下分析了使用的杀死途径 (依赖和CD95-CD95L).
主要成果:
- 由瘤IgVH激活的CD8+ T细胞通过穿孔素和CD95-CD95L通路杀死目标.
- 当受生殖线IgVH的刺激时,该在MHC结合槽中以单个氨基酸不同,CD8+ T细胞仅通过CD95-CD95L通路杀死目标.
- 这表明,CD95-CD95L介导的杀死可以被选择性地激活,而不依赖于穿孔素的杀死.
结论:
- 由MHC分子呈现的结构的轻微改变可以明显调节CD8+T细胞细胞毒性机制.
- CD95-CD95L通路为CD8+ T细胞介导的细胞毒性提供了一种独特且可选择性触发的途径.
- 受结合影响的MHC构造的变化,在确定CD8+T细胞利用的特定细胞毒性途径方面发挥着关键作用.
相关概念视频
Antigens Involved in Adaptive Immunity
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
T Cell Activation and Clonal Selection
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
T Cell Types and Functions
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Cytotoxic T Cells-mediated Immune Response
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
B Cell Activation and Differentiation
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
Immune Response Against Viral Pathogens
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...


