在248名患有手术诊断评估的患者的结局
B G Vickrey1, R D Hays, R Rausch
1Department of Neurology, University of California, Los Angeles, USA.
Lancet (London, England)
|December 2, 1995
概括
手术显著减少了发作频率和抗药物的使用. 虽然手术改善了一些生活质量的方面,但它对就业和整体生活质量的影响需要在更大的研究中进一步调查.
科学领域:
- 神经外科 神经外科
- 发病学 (Epileptology) 是一个专业的学科.
- 临床神经学 临床神经学
背景情况:
- 吸收性手术是一种常见的治疗方法,但其有效性并未通过随机试验得到充分证实.
- 评估手术结果需要评估发作,药物,就业和生活质量.
研究的目的:
- 评估手术对控制,药物减少,就业和生活质量的影响.
- 为了比较接受手术的患者和没有接受手术的患者之间的结果.
主要方法:
- 在1974年至1990年间,对248名成年和青少年患者进行了回顾性分析.
- 通过自行管理问卷和对202名手术和46名非手术患者的医疗记录审查收集的数据.
- 对基线共变量进行统计调整,以比较结果.
主要成果:
- 手术患者的每月发作频率下降较大 (-11.9 vs -1.5) 并使用较少的抗药 (1.4 vs 2.0).
- 在随访时使用的11个尺度中的5个,在手术患者中观察到更高的生活质量得分.
- 两组之间在就业状况或前性评估的生活质量方面没有发现显著差异.
结论:
- 与非手术治疗相比,手术导致更好地控制发作和减少药物治疗需求.
- 手术对生活质量和就业的长期影响需要更大规模的前性研究.
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