相关实验视频
输血后肝炎:非A型,非B型肝炎替代试验的影响. 加拿大输血后肝炎预防研究小组
M A Blajchman1, S B Bull, S V Feinman
1McMaster University, Hamilton, Ontario.
Lancet (London, England)
|January 7, 1995
概括
在加拿大实施非A,非B (NANB) 代孕标志物测试显著减少了输血后的肝炎,特别是C型肝炎病毒感染,在广泛的抗HCV查之前.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 输血医学 输血医学
- 传染性疾病 传染性疾病
背景情况:
- 加拿大对捐献血液缺乏非A,非B (NANB) 替代体标记测试,这构成了输血后肝炎的风险.
- NANB替代标记物,包括B型肝炎核心抗原和氨酸转移酶的抗体,并不是常规用于血液查.
研究的目的:
- 评估保留对NANB替代标记物阳性的血液在预防输血后肝炎的有效性.
- 评估NANB替代体测试对减少A,B,C型肝炎,爱斯坦-巴尔病毒 (EBV) 和细胞巨乳病毒 (CMV) 感染的影响.
主要方法:
- 一项前性随机干预研究,从1988年到1992年,涉及4588名受试者.
- 两组接受了异构血液:一组与NANB替代阳性单位保留 (n=2311),另一个没有保留 (n=2277).
- 还评估了接受同源血液的非随机队列 (n=650);所有受试者都被跟踪了6个月.
主要成果:
- 扣留NANB替代阳性单位将整体输血后肝炎降低了40% (p=0.065) 和C型肝炎降低了70% (p=0.05).
- 在抗HCV查前的期间,在没有保留的组中,C型肝炎病毒的发病率为12.6/1000,而在保留组中为0 (p=0.06).
- 在引入抗HCV查后,整体输血后肝炎发病率在各组之间相似 (8.6对6.8每1000人;p=0.55).
结论:
- NANB替代体标志物测试表明,在减少输血后肝炎方面具有显著的益处,主要是由于降低了C型肝炎病毒传播.
- 代孕标志物测试的影响在实施通用抗HCV查之前是最明显的.
- 这些发现支持替代体标记测试在提高血液安全方面的实用性,特别是在资源有限的环境中或在过渡到直接病毒测试期间.
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