神经板细胞的背部分化由BMP介导的信号诱导,来自表皮外皮
K F Liem1, G Tremml, H Roelink
1Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA.
Cell
|September 22, 1995
概括
神经原始细胞分化成背脊细胞类型是由相反的信号控制的. 外皮外皮提供BMP介导的背部化信号,而心弦则提供Sonic hedgehog (SHH) 介导的腹部化信号.
科学领域:
- 发育生物学是发展生物学.
- 分子生物学分子生物学
- 神经科学是一个神经科学.
背景情况:
- 细胞相互作用指导神经前代的分化.
- 背细胞类型的规范涉及复杂的信号通路.
研究的目的:
- 研究控制脊柱细胞类型与神经前代分化的细胞和分子机制.
- 阐明特定信号分子在确定背部神经命运中的作用.
主要方法:
- 神经板爆炸物的分析.
- 对基因表达模式的检查.
- 使用BMP和SHH信号通路的功能研究.
主要成果:
- 脊椎基因表达最初在神经板中均,受Sonic hedgehog (SHH) 限制.
- 来自表皮外皮外皮的接触依赖信号,包括BMP4和BMP7,诱导背部命运.
- 随后,BMP4和DSL1在背部神经管中得到表达.
结论:
- 背脊细胞分化始于神经板阶段.
- 对立的BMP介导的背部化信号和SHH介导的腹部化信号调节背部腹部模式.
- 表皮外皮和记带信号之间的平衡对于背皮细胞命运的获得至关重要.
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