免疫球蛋白和左心室的结构和功能在儿科艾滋病毒感染
S E Lipshultz1, E J Orav, S P Sanders
1Department of Cardiology, Children's Hospital, Boston, MA 02115, USA.
Circulation
|October 15, 1995
概括
静脉注射免疫球蛋白 (IVIG) 治疗和更高的免疫球蛋白IgG水平改善了HIV感染儿童的左心室 (LV) 结构和功能. 这表明免疫调节可能有助于治疗与艾滋病毒有关的心脏功能障碍.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 渐进的左心室 (LV) 扩张在儿科HIV-1感染中很常见,可能导致充血性心力衰竭 (CHF).
- 这些儿童的 LV 功能障碍通常与不充分的缩,增加后负载和功能减弱有关.
- 之前的观察表明,在其他条件下,静脉注射免疫球蛋白 (IVIG) 可能改善CHF.
研究的目的:
- 为了研究免疫球蛋白水平和LV结构/功能在没有心血管疾病的HIV感染儿童之间的关系.
- 探索 LV 功能障碍在儿科HIV中的潜在免疫学基础.
主要方法:
- 对49名艾滋病毒感染婴儿和没有心血管疾病的儿童进行了回顾性分析.
- 在血清免疫球蛋白 (IgG,IgA,IgM) 测量后的30天内进行了106次心声回声图.
- 对年龄,身体表面积和其他临床因素进行调整的重复测量回归分析.
主要成果:
- 更高的内源性IgG水平和IVIG治疗与增加的LV壁厚度和减少峰值壁应力相关.
- 增加的内源性IgA水平与更正常的LV壁厚度和厚度与尺寸比率有关.
- 随着更高的免疫球蛋白水平或IVIG治疗,观察到改善LV收缩性,分数缩短和终止缩壁应激的趋势.
结论:
- 在接受IVIG或具有更高内源性IgG水平的HIV感染儿童中,LV结构和功能更正常.
- 这些发现支持这样一个假设,即儿科艾滋病毒中心肌生长受损和LV功能障碍是免疫介导的.
- 免疫调节疗法,如IVIG,可能有利于管理这一群体的LV功能障碍.
更多相关视频
07:21Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment
Published on: June 23, 2019
08:12Isolation of Leukocytes from Human Breast Milk for Use in an Antibody-dependent Cellular Phagocytosis Assay of HIV Targets
Published on: September 6, 2019
相关概念视频
Humoral Immune Responses
Overview
Antibody Structure
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibody Structure and Classes
Antibodies, also known as immunoglobulins, are produced by B cells in response to foreign substances, such as bacteria and viruses. These proteins are critical for recognizing and neutralizing these substances, protecting the body from potential harm.
The basic structure of an antibody consists of four protein chains: two identical heavy chains and two identical light chains. These chains are held together by disulfide bonds and other non-covalent interactions, forming a Y-shaped structure.
The basic structure of an antibody consists of four protein chains: two identical heavy chains and two identical light chains. These chains are held together by disulfide bonds and other non-covalent interactions, forming a Y-shaped structure.
Development of Immunocompetence
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Immunodeficiency Diseases
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
There are three main causes of immunodeficiency disorders...
Inhibitors of Virion Maturation and Assembly
As part of their replication cycle, certain viruses synthesize long precursor proteins called polyproteins within infected host cells. In human immunodeficiency virus (HIV), two major polyproteins are produced: Gag and Gag-Pol. The Gag polyprotein supplies the structural components of the virus, while Gag-Pol includes essential viral enzymes such as reverse transcriptase, integrase, and protease. After synthesis, these polyproteins move to the host cell membrane, where they assemble into an...
