评估一种普遍的,以学校为基础的乙型肝炎疫苗接种计划
S Dobson1, D Scheifele, A Bell
1Vaccine Evaluation Center, British Columbia's Children's Hospital, Vancouver, Canada.
JAMA
|October 18, 1995
概括
英国哥伦比亚省6年级学生的乙型肝炎疫苗接种计划非常成功,接受率和完成率很好. 该疫苗被证明是安全和高效的,在98%的学生中达到保护性抗体水平.
科学领域:
- 公共卫生 公共卫生
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 乙型肝炎对全球健康构成重大风险.
- 全民疫苗接种计划对于疾病控制至关重要.
- 基于学校的疫苗接种提供了一个高效的交付模式.
研究的目的:
- 为了评估不列颠哥伦比亚省6年级学生的乙型肝炎疫苗接种计划.
- 评估计划的可接受性,完成率和安全性.
- 确定疫苗免疫性和不良事件概况.
主要方法:
- 在加拿大不列颠哥伦比亚省的队列研究设计.
- 恩格里克斯-B疫苗在0个月,1个月和6个月时进行.
- 监控接受,完成,不良事件和血清反应.
主要成果:
- 实现了高招生率 (95.4%) 和系列完成率 (95.6%).
- 轻微的不良事件很少发生;严重的事件很少发生 (例如,一次过敏反应).
- 98%的学生在接种疫苗后达到保护性抗体水平.
结论:
- 学校为青春期前儿童接种乙型肝炎疫苗是非常可接受和有效的.
- 该计划证明了强大的安全性和免疫性.
- 支持扩大类似的公共卫生倡议.
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