Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Identification of mega-environments and rice genotypes for general and specific adaptation to saline and alkaline stresses in India.

Scientific reports·2017
Same author

Peripheral T-Cell Lymphoma-A Brief Review.

Leukemia & lymphoma·2016
Same author

Recurrent activating mutations of CD28 in peripheral T-cell lymphomas.

Leukemia·2016
Same author

A prognostic model predicting autologous transplantation outcomes in children, adolescents and young adults with Hodgkin lymphoma.

Bone marrow transplantation·2015
Same author

Allogeneic hematopoietic cell transplantation for mycosis fungoides and Sezary syndrome.

Bone marrow transplantation·2014
Same author

The control of NAD specific malic enzyme from cauliflower bud mitochondria by metabolites.

Planta·2014

相关实验视频

Updated: Jul 29, 2026

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
06:39

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Published on: October 3, 2018

在骨髓移植中出现多器官功能障碍综合征

W D Haire1, E I Ruby, B G Gordon

  • 1Department of Internal Medicine, University of Nebraska Medical Center, Omaha 68198-3330, USA.

JAMA
|October 25, 1995
PubMed
概括

骨髓移植 (BMT) 中的器官功能障碍很常见,并且与较低的蛋白C (PC) 和抗素III (ATIII) 水平有关. 这些低水平与增加的死亡率和器官衰竭有关,这表明BMT并发症的作用.

更多相关视频

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
08:00

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

Published on: May 26, 2021

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells
05:32

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

Published on: February 16, 2024

相关实验视频

Last Updated: Jul 29, 2026

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
06:39

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Published on: October 3, 2018

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
08:00

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

Published on: May 26, 2021

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells
05:32

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

Published on: February 16, 2024

科学领域:

  • 血液学 血液学 血液学
  • 临界护理医学 临界护理医学
  • 移植免疫学 移植免疫学

背景情况:

  • 器官功能障碍是骨髓移植 (BMT) 后的一个重大并发症.
  • 在BMT患者中,特定的凝血因子和器官功能障碍之间的关系需要进一步阐明.

研究的目的:

  • 确定 BMT 患者器官功能障碍的发生率和结果.
  • 调查蛋白C (PC) 和抗素III (ATIII) 的降低水平是否与BMT后的器官功能障碍有关.

主要方法:

  • 一组199名接受BMT治疗的患者进行了28天的随访或直到医院出院/死亡.
  • 评估了器官功能障碍 (肺,中枢神经系统,肝脏,脏) 和PC和ATIII的水平.
  • 多变量分析被用来识别器官功能障碍的独立预测因素.

主要成果:

  • 单个器官功能障碍发生在48.5%的患者中,并预测多个器官功能障碍综合征 (MODS) 和死亡.
  • 较低的PC或ATIII水平与增加的死亡率和器官功能障碍有关.
  • ATIII和PC水平独立预测单个器官功能障碍,无论移植类型或细菌性.

结论:

  • 在BMT中,单个器官功能障碍作为系统异常的标志物,可以进展到MODS.
  • MODS是BMT患者的主要死亡原因.
  • 降低的ATIII和PC水平与BMT中的MODS病原性有关,突出了它们作为生物标志物的潜力.