在老年患者中冠状动脉鼻过敏的病理生理学
1Department of Geriatric Medicine, University of Birmingham, Birmingham B29 6JD, UK.
Lancet (London, England)
|October 7, 1995
概括
老年人患上冠状动脉鼻过敏 (CSH) 可能源于脑干受体的变化,而不仅仅是衰老. 这种导致头和跌倒的情况可能是更广泛的动脉样硬化疾病的标志物.
科学领域:
- 心脏病学 心脏病学
- 老年病的医生 老年病的医生
- 神经科学是一个神经科学.
背景情况:
- 冠状动脉鼻过敏 (CSH) 影响高达45%的老年患者出现昏,跌倒或头.
- 病理生理学尚不清楚,尽管与衰老,高血压和缺血性心脏病有关.
- 目前对心脏抑制性CSH的治疗方法存在,但对血管抑制性CSH的治疗方法是不满意的.
研究的目的:
- 为老年患者中CSH病理生理学的新假设提出建议.
- 调查α-2上腺受体在CSH中的作用.
- 将CSH重新定义为动脉硬化疾病的标志物.
主要方法:
- 该研究提出了一个基于现有文献和生理学原理的假设.
- 它提出了一种机制,涉及降低喉鼻顺应性和随后的巴罗反射路径改变.
- 专注于大脑干后突触α-2上腺受体的提议上调.
主要成果:
- 假设在动脉样性高血压患者中,心血管鼻腔的顺应性降低导致巴罗反射 afferent流量的减少.
- 表明这种"分化"会通过α-2氨基受体上调调引起 postsynaptic 过敏.
- 建议,动脉鼻刺激会引发过度反应,导致低血压和胆心梗塞.
结论:
- 在老年人中,CSH可能是由上调的大脑干后突触α-2上腺受体引起的.
- CSH可以作为广泛的动脉硬化疾病的临床标志物.
- 该假设对老年动脉样硬化患者低血压的药物治疗有影响.
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