概括
这项研究表明,非A,非B型肝炎是由传染性病原体引起的. 这种药物可以在慢性载体状态下持续存在,正如成功传播给黑猩猩所示.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 输血医学 输血医学
背景情况:
- 输血后肝炎 (P.T.H.) 是一种 是一个重大问题.
- 非A,非B型肝炎占P.T.H.的相当一部分. 一个案例,一个案例.
- 非A,非B型肝炎的致病原体仍未确定.
研究的目的:
- 调查负责非A,非B型肝炎的病原体的传染性.
- 为了确定急性或慢性肝炎病例是否可以传播疾病.
- 建立一个动物模型来研究非A,非B型肝炎.
主要方法:
- 用非A,非B型肝炎患者和献血者的血/血清对黑猩猩进行注射.
- 对黑猩猩进行生物化学 (阿氨酸转移酶 - ALT) 和肝炎组织学证据的监测.
- 黑猩猩和人类患者之间的潜伏期和ALT水平的比较.
- 对甲型肝炎和乙型肝炎病毒进行血清检测.
主要成果:
- 5只接种疫苗的黑猩猩中有5只发生肝炎,由生物化学和组织学数据证实.
- 黑猩猩的平均潜伏期为13.4周.
- 黑猩猩的高峰ALT水平有所不同,组织学变化与ALT升高相关.
- 没有发现甲型或乙型肝炎的证据;传染发生在急性和慢性病例中,表明慢性载体状态.
结论:
- 非A,非B型肝炎是由传染性病原体引起的.
- 病原体可以在慢性载体状态下持续存在,可能长期保持传染性.
- 黑猩猩是研究这种传染性肝炎病原体的可行模型.
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