从受污染的冷保存中传播乙型肝炎
R S Tedder1, M A Zuckerman, A H Goldstone
1Division of Virology, University College London Medical School, UK.
Lancet (London, England)
|July 15, 1995
概括
一个冷储泄漏导致B型肝炎病毒 (HBV) 在接受细胞毒性治疗的6名患者中传播. 这凸显了对捐赠者查和安全冷保存容器密封的关键需求,以防止血液传播病毒的传播.
科学领域:
- 病毒学 病毒学
- 血液学 血液学 血液学
- 移植医学 移植医学
背景情况:
- 接受细胞毒性治疗的多次输血患者容易受到感染.
- 骨髓或干细胞等生物材料的冷保存对于潜在的未来移植是常见的.
- 乙型肝炎病毒 (HBV) 是一个重要的血液传染病原体.
研究的目的:
- 为了调查六名患者急性乙型肝炎病毒 (HBV) 感染的原因.
- 在涉及冷保存组织的临床环境中确定HBV的传播途径.
- 强调组织冷保存和供体查安全措施的重要性.
主要方法:
- 在25个月的时间里,对患者病历和临床结果进行了回顾性分析.
- 在冷储存中的液中检测人类DNA,乙型肝炎表面抗原 (HBsAg) 和HBVDNA.
- 来自患者和冷保存的HBVDNA的序列分析,以确定相关性.
主要成果:
- 六名多次输血患者在接受冷保存的骨髓或干细胞后发展出急性HBV感染.
- 在冷保存的液和四名感染患者中发现了相同的HBVDNA序列.
- 证据表明,第一个感染患者的冷保存袋的泄漏污染了水箱,并传播了HBV.
结论:
- 冷保存袋的泄漏可能导致广泛的污染和HBV的传播.
- 严格的查组织捐赠者血液传播病毒是必不可少的.
- 主要的冷保存容器必须设计以防止与冷物质的物质交换,以确保患者的安全.
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