在口服耐受性中,对抗原反应性T细胞的外周删除
1Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Nature
|July 13, 1995
概括
口服抗原诱导免疫耐受性通过删除抗原反应性T细胞. 这一过程取决于抗原剂量,涉及亡和细胞因子的产生,为口服耐受性机制提供了新的见解.
科学领域:
- 免疫学 免疫学 免疫学
- 口服耐受性诱导方法
- 关于T细胞的规则
背景情况:
- 口服抗原是一种诱导抗原特异性外周免疫耐受性的关键方法.
- 口服耐受性防止全身免疫反应,并可以通过向自身抗原来抑制自身免疫疾病.
- 口服耐受性的机制包括活性抑制和克隆性无能,受抗原剂量的影响.
研究的目的:
- 研究口服抗原诱导免疫耐受性的机制.
- 为了确定T细胞删除在Peyer贴片中的作用,口服抗原给药后.
- 阐明口服抗原对T细胞反应和细胞因子生产的剂量依赖作用.
主要方法:
- 利用具有卵泡蛋白特异性T细胞受体基因的转基因小鼠.
- 通过口服给予卵胺以诱导耐受性.
- 在皮耶尔贴片中分析了T细胞删除,细胞灭亡和细胞因子 (TGF-β,IL-4,IL-10) 概况.
- 改变抗原剂量和养频率,以评估剂量依赖的影响.
主要成果:
- 口服抗原给药导致皮耶尔贴片中抗原反应性T细胞的亡中介删除.
- 删除取决于抗原剂量和养频率.
- 较低的抗原剂量诱导产生TGF-β,IL-4和IL-10的抗原特异细胞,而没有显著的删除.
- 较高剂量导致Th1和Th2细胞的删除,TGF-β分泌细胞表现出耐药性.
结论:
- 口服的抗原通过抗原反应性Th1和Th2细胞的异位切除诱导免疫耐受性.
- 这种删除机制补充了先前已知的活跃抑制和克隆性厌氧的途径.
- 口服抗原的剂量和频率极大地影响耐受性诱导途径,影响T细胞命运和细胞因子概况.
相关概念视频
Cell-mediated Immune Responses
Overview
Special Features of Adaptive Immunity
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
Antigens Involved in Adaptive Immunity
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
T Cell Activation and Clonal Selection
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
T Cell Types and Functions
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Cytotoxic T Cells-mediated Immune Response
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...


