在怀疑格拉姆阴性败血症后的长期生存和功能
1Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242, USA.
JAMA
|July 26, 1995
概括
严重的潜在疾病和血管压缩剂的使用预测了败血症的生存率. 幸存者经常经历身体功能障碍和一般健康状况较差,尽管情绪健康可能会改善.
科学领域:
- 临界护理医学 临界护理医学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 格拉姆阴性败血症对患者的生存和长期健康构成重大威胁.
- 预测败血症患者的长期结果对于资源配置和患者管理至关重要.
研究的目的:
- 为了确定长期存活率 (>3个月) 在患有格兰阴性败血症的患者.
- 开发用于长期败血症生存的预测模型.
- 评估败血症幸存者的健康和功能状态.
主要方法:
- 一组100名怀疑患有грам阴性败血症的患者被随访了平均7667个患者月.
- 考克斯比例危险回归模型被用来确定长期生存的预测因素.
- 使用经过验证的评分系统测量健康和功能状态,并与一般人口规范进行比较.
主要成果:
- 潜在疾病的严重程度 (McCabe和Jackson标准) 和血管压缩剂的使用是死亡率的重要预测因素.
- 成年呼吸系统应急综合征和并发性疾病也预测了长期生存率不佳.
- 败血症幸存者报告说,身体功能障碍增加和一般健康感知较差,但情绪健康感知有所改善.
结论:
- 基础疾病的严重程度和在败血症开始时使用血管压缩剂强烈预测短期和长期生存.
- 麦凯布和杰克逊的严重程度评分系统已被验证用于预测长期败血症生存率.
- 身体功能障碍和整体健康感知下降是败血症的常见后果,需要持续的患者支持.
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