阿齐思罗米用于男性非菌性尿路炎综合征的经验性治疗. 一个随机的双盲研究
W E Stamm1, C B Hicks, D H Martin
1University of Washington, Seattle, USA.
JAMA
|August 16, 1995
概括
单次口服阿齐思罗米剂量有效治疗男性的非冠状病毒球菌性尿路炎,其临床治愈率与7天多西环林疗程相当. 这项研究评估了阿齐思罗米辛与多西环林的治疗这种常见的性传播感染.
科学领域:
- 传染性疾病 传染性疾病
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 药理学 药理学是指药理学的学科.
背景情况:
- 非菌性尿路炎 (NGU) 是男性常见的性传播感染 (STI).
- 经验性治疗通常在确定微生物学诊断之前开始.
- 标准治疗通常涉及多西环林的7天疗程.
研究的目的:
- 为了评估单次口服剂量阿齐思罗米与多克西环林在经验性治疗NGU的疗效和安全性.
- 评估克拉米迪亚甲状腺菌和Ureaplasma urealyticum感染的临床和微生物治愈率.
主要方法:
- 进行了一项随机的,双盲的多中心试验.
- 452名患有症状NGU的男性被随机分为2:1接受一次1.0g剂量的亚齐思罗米或100mg的多西环素每天两次,持续7天.
- 在治疗前和治疗后2周和5周进行了临床和微生物学评估.
主要成果:
- 亚齐思罗米的临床治愈率为81%,多西环素的临床治愈率为77%,显示出相似的疗效.
- 甲状腺炎菌的微生物学治愈率为83% (亚胺素) 和90% (多西环素).
- 微生物治疗Ureaplasma urealyticum的治疗率为45% (亚齐思罗米) 和47% (多西环素).
- 副作用的程度为轻度至中度,发生在23%的阿齐思罗米辛组和29%的多西环素组中.
结论:
- 单次口服阿齐思罗米剂量与7天多西环林疗程在男性急性非冠状菌性尿路炎的实证治疗中同样有效.
- 两种疗法都实现了可比的临床治愈率,不论是否存在克拉米迪亚或尿液等离子体感染.
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