和慢性肝脏脑病变 - 长期肝脏脑病变
D Krieger1, S Krieger, O Jansen
1Department of Neurology, Ruprecht-Karls University of Heidelberg, Germany.
Lancet (London, England)
|July 29, 1995
概括
(Mn) 在肝衰竭患者的基底中积聚,可能导致神经毒性. 这种金属积累可能在慢性肝脑病变中起作用,这表明了新的治疗途径.
科学领域:
- 神经科学是一个神经科学.
- 肝病学 肝病学是一种肝病学.
- 毒理学 毒理学 毒理学
背景情况:
- 临床观察和动物研究表明,在末期肝病中,血中 (Mn) 含量升高和基底腺积累之间存在联系.
- 慢性肝脑病变 (CHE) 是一种与肝功能衰竭相关的神经精神综合征,其潜在机制尚不清楚.
研究的目的:
- 为了研究患有肝功能衰竭的患者的基底腺中的 (Mn) 积累.
- 探索Mn在慢性肝脑病变 (CHE) 病变发生过程中的潜在作用.
主要方法:
- 磁共振成像 (MRI) 用于研究10名肝衰竭患者和10名对照患者.
- 测量全血和脑组织样本中Mn度的患者和对照.
主要成果:
- 与对照组相比,肝硬化患者的全血Mn度显著增加 (34.4μg/L与10.3μg/L).
- 在MRI上,体信号强度与血液Mn水平相关 (Rs = 0.8,p = 0.0058).
- 脑组织分析显示,最高的Mn度在尾状核中,其次是四肢板和白色球.
结论:
- (Mn) 在肝硬化患者的基底中明显积累.
- 这些发现表明Mn神经毒性可能有助于慢性肝脑病变 (CHE) 的发病.
- 进一步研究合剂作为CHE的治疗策略是有必要的.
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