在不失败的人类心脏中重新极化K+电流. 右隔膜下心脏和左心脏下心室肌细胞之间的相似之处
H Konarzewska1, G A Peeters, M C Sanguinetti
1Division of Cardiology, Eccles Institute of Human Genetics, University of Utah, Salt Lake City 84112, USA.
Circulation
|September 1, 1995
概括
人类心室K+电流 (IK1和Ito1) 在心室间隔膜中显示区域相似性,与之前在左心室自由壁的发现不同. 这些共享的电气特性可能对隔膜收缩具有功能意义.
科学领域:
- 心脏病学 心脏病学
- 电子生理学 电子生理学
- 分子生物学分子生物学
背景情况:
- 心脏再极化涉及各种K+通道,其特性取决于组织和物种.
- 之前的研究发现左心室 (LV) 下心脏和下内心肌细胞之间短暂的外向K+电流 (Ito1) 的差异.
- 与右心室 (RV) 隔膜一起工作的右心室 (RV) 隔膜的电性质仍然不太了解.
研究的目的:
- 为了比较人类心脏K+电流的特征 (Ito1和内向整流器K+电流[IK1]) 来自LV下心脏和RV隔膜下心脏的肌细胞.
- 调查这些地区之间潜在的功能电气相似之处.
主要方法:
- 肌细胞从RV隔膜下心脏活检和LV下心脏组织中分离出来.
- 进行了电生理学记录,以测量IK1和Ito1的振幅和特性.
- 从两个区域的肌细胞进行了比较.
主要成果:
- 在心下和隔膜下心内肌细胞之间,IK1的幅度一致.
- 伊托1的幅度在LV下心脏肌细胞和RV隔膜下心脏肌细胞中仅略大.
- 伊托1的关键特征 (电压依赖性,无活化,恢复) 在两个区域都相似,与LV无壁的发现形成鲜明对比.
结论:
- 人类心室IK1和Ito1在RV隔膜下心脏细胞和LV下心脏细胞中表现出类似的特性.
- 这些发现与以前关于LV自由壁亚内心肌细胞的报道有所不同.
- 电同质性表明RV隔膜在心室收缩中的作用具有功能意义.
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