腹腔大动脉动脉瘤的兄弟风险
P A Baird1, A D Sadovnick, I M Yee
1Department of Medical Genetics, University of British Columbia, Vancouver, Canada.
Lancet (London, England)
|September 2, 1995
概括
腹腔大动脉瘤 (AAA) 患者的一级亲属患有AAA的风险明显更高. 建议对AAA患者的兄弟姐妹通过超声波进行早期查,这是由于早期发病和患病率增加.
科学领域:
- 血管外科 血管外科
- 遗传学 是一个遗传学.
- 流行病学 流行病学
背景情况:
- 在一级亲属中,腹腔大动脉瘤 (AAA) 的风险较高.
- AAA的家族聚合表明有一个遗传成分.
研究的目的:
- 与对照组相比,研究AAA患者兄弟姐妹的AAA发病风险和发病年龄.
- 评估超声波查在这个高风险群体中的有用性.
主要方法:
- 一项为期3年的前性研究,将AAA试验患者的兄弟姐妹 (n=427) 与对照患者的兄弟姐妹 (n=451) 进行比较.
- 通过采访收集的遗传信息;通过医疗记录验证确定受影响的状态.
- 对兄弟姐妹和对照组的一个子集进行超声波查.
主要成果:
- AAA试验者的兄弟姐妹比对照兄弟姐妹 (1.1%) 的AAA患病率更高 (4.4%).
- 83岁时AAA的终身累积风险在试验者的兄弟姐妹 (11.7%) 和对照者的兄弟姐妹 (7.5%) 中较高.
- 超声波显示,与对照组 (8%) 相比,试验者的兄弟姐妹 (19%) 的AAA患病率显著更高,并且观察到更早的发病.
结论:
- 家庭因素显著影响腹腔大动脉动脉瘤的发病年龄和风险.
- 建议对被诊断患有AAA的患者的兄弟姐妹进行例行超声波查,以促进早期检测.
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