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Affinity Precipitation of Active Rho-GEFs Using a GST-tagged Mutant Rho Protein (GST-RhoA(G17A)) from Epithelial Cell Lysates
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关氨酸核酸交换因子人类Mss4的结构及其Rab交互表面的识别

H Yu1, S L Schreiber

  • 1Howard Hughes Medical Institute, Department of Chemistry, Harvard University, Cambridge, Massachusetts 02138, USA.

Nature
|August 31, 1995
PubMed
概括

人类Mss4 (hMss4),一种瓜核酸交换因子 (GEF),具有确定的三级结构. 这种结构揭示了它的活性部位涉及到一个Zn2+结合区域和一个邻近的循环,这对Rab蛋白调节至关重要.

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