产前酒精暴露和长期发展后果
H L Spohr1, J Willms, H C Steinhausen
1Department of Pediatrics, Rittberg Hospital of the German Red Cross, Berlin.
Lancet (London, England)
|April 10, 1993
概括
胎儿酒精综合征 (FAS) 可以导致持久的智力残疾. 这项为期10年的研究表明,FAS面特征可能会消失,但小头症和认知缺陷往往持续到青春期.
科学领域:
- 神经科学是一个神经科学.
- 儿科 儿科 儿科
- 遗传学 是一个遗传学.
背景情况:
- 胎儿酒精综合征 (FAS) 是可预防的智力障碍的一个重要原因.
- 对于患有FAS的儿童的长期发育结果和青少年发展轨迹仍然不完全理解.
研究的目的:
- 在被诊断为FAS的儿童中调查子宫内酒精暴露的长期后果.
- 评估从婴儿期到青春期的发育变化和持续影响.
主要方法:
- 一项为期10年的纵向随访研究.
- 涉及60名在婴儿或儿童时期被诊断患有FAS的患者.
- 随着时间的推移,评估了身体成长,面特征和认知发展.
主要成果:
- 与FAS相关的特征性面形倾向于随着年龄的增长而减少.
- 在大多数情况下,小头仍然存在;观察到身高矮和体重不足,特别是在青少年男孩中.
- 智力发展表现出持续的赤字,环境或教育干预的补偿效应有限.
结论:
- 宫内酒精暴露导致FAS儿童持续的发育挑战.
- 虽然一些身体特征可能会减弱,但小头症和智力障碍仍然是显著的长期后果.
- 早期干预和环境支持对缓解FAS的核心认知缺陷的影响有限.
相关概念视频
Teratogenicity
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
CNS Depressants: Alcohol and Nicotine
Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
Attention-Deficit/Hyperactivity Disorder
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings.


