人类疹病毒感染自然杀手细胞 6
P Lusso1, M S Malnati, A Garzino-Demo
1Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
Nature
|April 1, 1993
概括
人类疹病毒6 (HHV-6) 感染并杀死自然杀手 (NK) 细胞. 这种感染还使NK细胞易受人类免疫缺陷病毒1型 (HIV-1) 感染,可能削弱免疫系统的抗病毒防御.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 细胞生物学 细胞生物学
背景情况:
- 自然杀手 (NK) 细胞对抗病毒感染和癌症的天生的免疫力至关重要.
- 在获得性免疫缺陷综合征 (艾滋病) 和慢性疲劳综合征等疾病中观察到缺陷NK细胞活性.
- 人类疹病毒6 (HHV-6) 是一种已知感染T淋巴细胞的DNA病毒.
研究的目的:
- 研究功能性NK细胞对HHV-6感染的易感性.
- 确定HHV-6感染对NK细胞功能的影响以及对其他病毒的敏感性.
- 阐明HHV-6在与NK细胞活动受损相关的疾病的发病中的作用.
主要方法:
- 功能性CD3-NK细胞克隆的隔离和培养.
- 产生性感染NK细胞克隆的HHV-6.
- 在感染后分析NK细胞活力和功能.
- 使用流式细胞计量对感染NK细胞的CD4受体表达的评估.
主要成果:
- 具有功能能力的NK细胞克隆被HHV-6有效感染.
- HHV-6感染是细胞病变的,导致NK细胞死亡.
- 受感染的NK细胞表现出CD4受体的新表达.
- 感染NK细胞上的CD4表达使它们易于感染人类免疫缺陷病毒1型 (HIV-1) 感染.
结论:
- HHV-6直接准并感染NK细胞,危及先天抗病毒免疫的关键组成部分.
- 对NK细胞的HHV-6感染可能会为HIV-1的进入和复制创造一个途径.
- 这种机制提供了一个潜在的策略,通过这种策略,疹病毒可以颠覆宿主抗病毒防御.
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