血清前列腺特异性抗原在健康男性的社区人口. 建立特定年龄的参考范围
J E Oesterling1, S J Jacobsen, C G Chute
1Department of Urology, Mayo Clinic and Foundation, Rochester, Minn. 55905.
JAMA
|August 18, 1993
概括
血清前列腺特异性抗原 (PSA) 水平随年龄和前列腺大小而增加. 建议对PSA进行特定年龄的参考范围,以更准确地检测男性的前列腺癌.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 生物标志物 生物标志物
背景情况:
- 前列腺特异性抗原 (PSA) 是前列腺癌的关键生物标志物.
- 确定PSA准确的参考范围对于早期检测至关重要.
- 影响PSA水平的因素,如年龄和前列腺大小,需要详细描述.
研究的目的:
- 确定患前列腺癌风险较高的健康男性血清PSA特征.
- 评估患者年龄和前列腺大小对血清PSA的影响.
- 改善PSA的适当使用,以便早期和准确地检测前列腺癌.
主要方法:
- 一项基于社区的前性研究,涉及471名40-79岁的健康男性.
- 血清PSA水平,数字直肠检查和跨直肠超声波检查进行.
- 血清PSA密度计算为血清PSA除以前列腺体积.
主要成果:
- 血清PSA度与患者年龄 (r=0.43) 和前列腺体积 (r=0.55) 正相关.
- 前列腺体积也与年龄相关 (r=0.43).
- 为PSA建立了特定年龄的第95百分点参考范围,从0.0-2.5 ng/mL (40-49岁) 到0.0-6.5 ng/mL (70-79岁) 不同.
结论:
- 血清PSA水平受到年龄和前列腺大小的显著影响.
- 特定年龄的PSA参考范围比单一的通用范围更合适.
- 实施特定年龄的范围可以提高PSA作为瘤标记物的有效性,以改善癌症检测和特异性.
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