左心室收缩率预测了狗的节奏诱导性缺血期间,终端腹压体积关系如何变化
1Department of Medicine, University of California, San Francisco 94143-0124, USA.
Circulation
|May 1, 1995
概括
左心室收缩性显著影响节奏诱导性缺血期间的末端腹压体积关系 (EDPVR) 转移. 收缩率下降导致EDPVR向下和向右转移,影响透气功能评估.
科学领域:
- 心脏病学 心脏病学
- 身体生理学 身体生理学
背景情况:
- 左心室的扩张性质在节奏诱导的缺血和冠状动脉闭塞诱导的缺血之间有所不同.
- 在缺血期间的末端透气压力-体积关系 (EDPVR) 转移方向是可变的.
- 在节奏诱导性缺血期间EDPVR转移的决定因素需要进一步调查.
研究的目的:
- 确定在节奏诱导性缺血期间,终端腹压压积关系 (EDPVR) 转移的关键决定因素.
主要方法:
- 在麻醉狗的46个节奏诱导性缺血实验的回顾性分析.
- 通过导电导管测量左心室体积;记录血液动力学.
- 使用上升和右移指数量化EDPVR转移.
主要成果:
- 左心室收缩性指数 (末性弹性[Ees]和dP/dtmax斜率) 是EDPVR转移的最强决定因素.
- 降低Ees或dP/dtmax斜率与向上偏移 (SI-S) 的降低和向右偏移 (delta EDVI-S) 的增加相关.
结论:
- 左心室收缩性是EDPVR转移方向的主要决定因素,在节奏诱导性缺血期间.
- 减少收缩性导致EDPVR向下和向右移动.
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