,

B M Forman1, K Umesono, J Chen

  • 1Salk Institute for Biological Studies, San Diego, California, USA.

Cell
|May 19, 1995
PubMed
概括

核受体异构体,如那些涉及9-cis视网膜酸受体 (RXR) 的异构体,可以表现出独特的荷尔蒙反应. 体相互作用创造了多样化的激素反应网络.

相关概念视频

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Internal Receptors01:31

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Internal Receptors01:31

Internal Receptors

Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
Types of Receptors: Internal Receptors01:07

Types of Receptors: Internal Receptors

Many cellular signals are hydrophilic and cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind intracellular receptors that reside within the cell cytoplasm or nucleus. Many mammalian steroid hormones and nitric oxide (NO) gas use this cell signaling mechanism.
Similar to membrane-bound receptors, the binding of a ligand to the intracellular receptor of causes a conformational change in the...