冠状动脉血管塑造术后的纤维素素是复原症的风险因素
G Montalescot1, A Ankri, E Vicaut
1Department of Cardiology, Centre Hospitalier Universitaire Pitié-Salpétrière, Paris, France.
Circulation
|July 1, 1995
概括
冠状动脉血管塑造术后纤维素水平升高预示着静脉缩,这是动脉样硬化的加快形式. ·威尔布兰德因子也独立地与内再生术后的过程有关.
科学领域:
- 心血管医学 心血管医学
- 干预心脏病学 干预心脏病学
- 临床生物化学 临床生物化学
背景情况:
- 纤维素素是一种已知的心血管疾病风险因素,与冠状动脉样硬化严重程度有关.
- 在冠状动脉血管塑造术后纤维素素在静止病的特定作用以前是未知的.
- 有限的数据存在于凝血和纤维溶解蛋白与血管形成术后复原症的关系.
研究的目的:
- 研究关键凝血和纤维溶解蛋白质的血水平与冠状动脉血管塑性手术后复原的发生之间的关联.
- 根据各种血管学定义来确定特定的蛋白质是否预测复原.
主要方法:
- 107名接受冠状动脉血管造形手术的患者的血含量测定了t-PA,PAI-1,·威尔布兰德因子和纤维素.
- 定量冠状动脉血管学评估了内直径的变化.
- 使用四个标准来定义静脉缩,包括>50%的最终静脉缩和光线直径的损失.
- 单变量和多变量分析将蛋白质水平与复原症定义相关联.
主要成果:
- 在这四个定义中,静止病的发病率从30%到48%不等.
- 血中的t-PA和PAI-1水平与静脉复缩无关.
- ·维勒布兰德因子测量立即血管造形术后预测的复缩由两个定义.
- 随访时纤维素素水平升高 (>3.5 g/L) 与更高的复原率 (55%对22%,P=.001) 有显著的关联.
- 纤维素水平与血管学损失指数 (r=0.41,P<.0001) 有显著的相关性.
结论:
- ·威尔布兰德因子独立地预测了由内生长所定义的复缩.
- 随访期间纤维素素水平升高是一个强烈的生化预测器的复原.
- 纤维素原应被视为静脉缩的独立标志物和动脉样硬化潜在的共同危险因素.
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