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在初级子宫部查中对人类乳头瘤病毒进行检测.

J Cuzick¹, A Szarewski, G Terry

¹Department of Mathematics, Statistics, and Epidemiology, Imperial Cancer Research Fund, London, UK.

Lancet (London, England)

|June 17, 1995

概括

人类乳头瘤病毒 (HPV) 检测可以检测宫内皮质瘤 (CIN) 2 / 3病变被常规细胞学遗漏. 虽然HPV检测在增强宫癌查方面表现有希望,但它不应该取代现有的方法.

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科学领域:

妇科妇科妇科妇科
在瘤学瘤学.
病毒学病毒学

背景情况:

宫癌查依赖于细胞学,但有些病变被遗漏了.
人类乳头瘤病毒 (HPV) 检测在改善检测中的作用仍然不清楚.

研究的目的:

评估针对特定类型 (16,18,31,33) 的HPV检测在检测宫内皮质瘤 (CIN) 2/3的有效性,在例行查期间.

主要方法:

在接受常规宫检查的妇女的样本上进行了HPV检测.
患有硬化症或HPV水平高的妇女被转诊进行大肠镜检查.
对HPV类型16,18,31和33的检测率和积极预测值进行了分析.

主要成果:

通过HPV检测,发现了44%的CIN 2/3病变具有负细胞学.
另外22%的CIN 2/3病变显示HPV阳性与轻度或边界细胞学.
与类型18和33相比,HPV类型16和31对CIN 2/3的敏感性和特异性更高,尽管这些四种类型错过了25%的CIN 2/3病变.

结论:

HPV 检测可以补充,但不能取代,用于宫癌查的常规细胞学.
需要进一步的大规模随机试验来评估HPV测试对侵袭性宫癌发病率的影响.