在血清中,Pobenecid和Rifampicin的水平较高
Lancet (London, England)
|October 25, 1975
概括
当Pobenecid与降低剂量一起使用时,它不会有效地增加血清里法匹辛水平. 因此,在结核病治疗中,不应使用probenecid来降低利法素剂量.
科学领域:
- 药理学 药理学是指药理学的学科.
- 传染性疾病 传染性疾病
- 临床治疗学 临床治疗学
背景情况:
- 利芬素是结核病治疗的基石药物.
- 优化利芬素剂量和血清水平对于有效治疗和预防耐药性至关重要.
- 调查如何管理利法西因剂量和患者坚持治疗的方法是一个正在进行的研究领域.
研究的目的:
- 为了评估probenecid对血清里法匹辛度的影响.
- 为了确定probenecid是否可以在抗结核治疗中促进降低利芬素剂量.
主要方法:
- 在接受抗结核治疗的患者中测量了血清里芬皮辛水平.
- 一个队列接受了600毫克标准剂量的利法皮辛.
- 另一个队列接受了300毫克降低剂量的利芬素,预先与2克probenecid一起使用.
主要成果:
- 在300毫克里芬辛剂量前30分钟服用2克普罗贝尼西德,并未达到治疗性血清水平.
- 由此产生的血清度不到标准600毫克里芬素剂量所得到的度的一半.
- 这表明probenecid在降低剂量时增加利芬素生物可用性的有效性有限.
结论:
- 在抗结核治疗方案中,普罗贝尼西德不是降低利法素剂量的有效补充剂.
- 与较低剂量的利芬素一起使用普罗贝尼西德不会产生足够的血清度以进行有效的治疗.
- 由于疗效不足,临床指南不应该推probenecid作为降低利芬素剂量的策略.
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