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Updated: Aug 9, 2026

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
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对活细胞毒性T淋巴细胞T细胞抗原受体-连接体相互作用的CD8调节

I F Luescher1, E Vivier, A Layer

  • 1Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, Switzerland.

Nature
|January 26, 1995
PubMed
概括

CD8分子通过协调与主要基因相容性复合体 (MHC) I 类分子的相互作用,显著增强T细胞受体 (TCR) 连接体结合力. 这种CD8-TCR相互作用调节T细胞激活动态和温度依赖.

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