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Updated: Aug 9, 2026

Identification of Kinase-substrate Pairs Using High Throughput Screening
11:13

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蛋白质-铁氨酸激酶的催化特异性对于选择性信号传递至关重要

Z Songyang1, K L Carraway, M J Eck

  • 1Department of Medicine, Beth Israel Hospital, Boston, Massachusetts 02215.

Nature
|February 9, 1995
PubMed
概括

蛋白-氨酸激酶 (PTKs) 显示出独特的基质特异性,受其催化位点和SH2域的影响. 这种特异性对于细胞信号传输至关重要,并且可以通过突变改变,影响人类疾病.

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