间歇性通过皮肤的酸甘治疗. 在无酸盐间隔期间降低门值
J D Parker1, A B Parker, B Farrell
1Department of Medicine, Queen's University, Kingston General Hospital, Ont, Canada.
Circulation
|February 15, 1995
概括
间歇性通过皮肤的酸甘治疗稳定性心痛可以导致心痛门降低几个小时后,补丁去除. 这种运动耐受性下降需要仔细考虑治疗时间和患者监测.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 间歇性通过皮肤注射的酸甘用于稳定性心痛.
- 耐受性酸甘可以发展与持续治疗.
- 之前的研究表明,在贴片被移除后,胸痛门可能会降低.
研究的目的:
- 为了研究通过皮肤去除尼甘贴片在患有稳定性胸痛的患者中对胸痛值的影响.
- 为了确定关节值在贴片移除后的任何变化的持续时间.
主要方法:
- 进行了一项随机,双盲,安慰剂控制的交叉研究.
- 十二名患有稳定性胸痛的患者接受了跑步机测试.
- 患者接受了活性酸甘或安慰剂贴片,在移除后间隔测试.
主要成果:
- 观察到耐受性酸甘,因为8 AM测试显示,活性和安慰剂之间没有显著差异.
- 贴片去除与心痛 (P1) 和中度心痛 (P2) 发病时间的显著减少有关.
- 这些效应在去除后持续了2至6小时,心率或血压没有变化.
结论:
- 间歇性通过皮肤的酸甘治疗降低了静脉门在稳定性静脉患者的贴片移除后4-6小时.
- 潜在的机制可能涉及对酸甘应用的反监管反应.
- 这一发现对治疗胸痛和优化治疗计划有意义.
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