一种可能的前生物合成的潘泰氨酸,一个前体的辅酶A的合成
A D Keefe1, G L Newton, S L Miller
1Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla 92093.
Nature
|February 23, 1995
概括
辅酶A的成分可以通过简单的加热,形成 early life 的代谢系统的前体 pantetheine. 这支持了先于RNA世界的铁世界假设.
科学领域:
- 益生菌前生物化学
- 生命起源研究研究生命的起源.
- 生物化学 生物化学
背景情况:
- 辅酶A在酶反应中的作用表明了早期的生物重要性.
- 它的成分是可信的益生菌化合物.
- 类抗生素生物合成涉及辅酶A,将其与铁世界假说联系起来.
研究的目的:
- 为了研究协酶A.的丁氨酸部分的 prebiotic 合成.
- 探索基于辅酶A前体的早期代谢系统的潜力.
主要方法:
- 在40°C的温度下加热 pantoyl lactone,β-alanine 和cysteamine.
- 分析 Pantetheine 部分的合成.
主要成果:
- 在40°C时合成的Pantetheine部分的产量为几个百分比.
- 在低温下证明了氨基酸键的形成.
- 益生菌成分是高度溶解的,有利于在蒸发的水体中的度.
结论:
- 在温和的条件下,泛太氨酸的合成支持其在早期新陈代谢中的作用.
- 这些发现为 thioester 世界假设提供了间接证据.
- 同酶A及其前体可能在最早的代谢系统中起着至关重要的作用.
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