间歇性通过皮肤的酸甘治疗在胸痛. 在没有耐受性或反弹的情况下临床有效. 对于Minitran的有效性研究小组
J O Parker1, M H Amies, R W Hawkinson
1Queen's University, Kingston, Ontario, Canada.
Circulation
|March 1, 1995
概括
通过皮肤注射的酸甘贴片为30天内每天12小时提供抗风脉和抗缺血效益. 这种间歇性治疗有效地增加了运动持续时间,而不会引起酸盐耐受性或反弹效应.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 间歇性通过皮肤的酸甘治疗用于心痛.
- 之前的研究没有清楚地记录在整个贴片应用期间的长时间运动持续时间.
- 不同剂量的尼甘的疗效和作用时间,包括耐受性和反弹性,需要进一步评估.
研究的目的:
- 为了评估30天内每天12小时应用三次通过皮肤的尼特洛甘油剂的抗风脉和抗缺血作用.
- 为了评估耐受性和反弹的发展,间歇性通过皮肤酸甘治疗.
- 为了确定酸甘在心痛患者的疗效和作用时间.
主要方法:
- 进行了一项多中心,随机,双盲,安慰剂控制的试验.
- 患者接受了30天的每天12小时的皮肤过甘贴片或安慰剂.
- 跑步机运动测试在基线和在1,7,15,30天进行,应用后长达12小时.
主要成果:
- 所有的酸甘油组都显示了跑步机上步行时间的统计学上显著增加,与安慰剂相比,跑步机上步时间到中度胸痛增加了12小时.
- 二次疗效测量,如时间到1毫米的ST段抑郁,支持了主要发现.
- 在30天的研究期间,没有观察到耐受性或反弹现象的证据.
结论:
- 间歇性通过皮肤的酸甘治疗有效地增加了应用后12小时的运动持续时间.
- 在整个30天的治疗过程中,抗胰岛症效应得到维持.
- 这种间歇性剂量方案没有观察到显著的酸盐耐受性或反弹.
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