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Dissection of the Transversus Abdominis Muscle for Whole-mount Neuromuscular Junction Analysis
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在缺乏s-laminin/laminin beta 2的小鼠中,神经肌肉接口的异常分化

P G Noakes1, M Gautam, J Mudd

  • 1Department of Anatomy, Washington University Medical School, St Louis, Missouri 63110.

Nature
|March 16, 1995
PubMed
概括

肌肉细胞释放s-laminin,它是基底膜的关键组成部分,指导运动神经末端的发育. 这一发现揭示了关键的肌肉衍生信号调节突触形成.

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Laminins are the Adhesive Proteins of Basal Lamina00:55

Laminins are the Adhesive Proteins of Basal Lamina

Laminins are heterotrimeric proteins with high molecular mass found in the extracellular matrix. Each laminin molecule is composed of three chains, viz. alpha, beta, and gamma, coded by five, four, and three paralogous genes, respectively. Laminins are categories based on the compositions of the three chains.
In humans, the five forms of alpha chains are LAMA 1, LAMA 2, LAMA 3, LAMA 4, and LAMA 5. The four forms of beta chains are LAMB 1, LAMB 2, LAMB 3, and LAMB 4. The three forms of gamma...