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在Mycobacterium结核病的异化物标的晶体结构和功能

A Dessen1, A Quémard, J S Blanchard

  • 1Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461.

Science (New York, N.Y.)
|March 17, 1995
PubMed
概括

结核病中异化物耐药性与InhA蛋白的突变有关,影响其结合NADH的能力. InhA酶的这种结构变化通过改变必需脂肪酸合成来阻碍药物的疗效.

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