在非洲和当地的火山土壤内在的卡波西肉瘤
1Department of Clinical Sciences, London School of Hygiene and Tropical Medicine, UK.
Lancet (London, England)
|November 27, 1993
概括
非洲的特有卡波西肉瘤 (KS) 可能源于火山土壤暴露,可能与 podoconiosis 相关. 粘土矿物质通过脚吸收可能会引发淋巴损伤,增加男性对传染病原体的易感性.
科学领域:
- 环境流行病学环境流行病学
- 皮肤病学 皮肤病学
- 病理学 病理学 病理学
背景情况:
- 在非洲流行的卡波西肉瘤 (KS) 与地理因素和慢性淋巴 edem有关,类似于podoconiosis.
- 这两种情况都在火山高地地区普遍存在,这表明有共同的环境病因.
- 癌症起源于淋巴内皮,影响脚和腿.
研究的目的:
- 调查火山土壤暴露与特有卡波西肉瘤之间的潜在联系.
- 为了探索KS和podoconiosis之间的病原遗传关系.
- 识别导致KS病因的环境和传染因素.
主要方法:
- 在火山地区对KS和podoconiosis流行情况进行比较地理分析.
- 在podoconiosis患者的淋巴组织检查环境颗粒.
- 审查临床特征和风险因素,以流行性KS.
主要成果:
- 在podoconiosis患者的淋巴管中发现的火山土矿物质 (酸) 支持通过脚吸收.
- 慢性淋巴炎症和粘土阻塞导致淋巴,类似于podoconiosis.
- 地理重叠,淋巴内皮原点,以及对下肢的偏好都表明一个共同的原因.
结论:
- 通过脚部吸收的火山粘土矿物质的暴露是导致特有KS的可能因素.
- 粘土引起的淋巴损伤可能会损害局部免疫力,增加对传染病原体的敏感性.
- 地方性KS可能是由于环境暴露 (火山粘土) 和传染病原体的结合,特别是在易受感染的男性中.
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