慢性伤寒和副伤寒携带者癌症死亡率
C P Caygill1, M J Hill, M Braddick
1Pathology Division, Public Health Laboratory Service-Centre for Applied Microbiological Research, Porton Down, Wiltshire, UK.
Lancet (London, England)
|January 8, 1994
概括
慢性伤寒携带显著增加了胆囊癌的风险. 通过抗生素或手术消除长期携带者对于预防癌症至关重要.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 细菌可以从体内分泌物中产生致癌物质.
- 慢性膀感染与致癌物质有关.
- 研究胆囊感染和癌症风险是有必要的.
研究的目的:
- 为了确定慢性胆囊感染,特别是伤寒携带是否与癌症风险增加有关.
- 为了比较慢性伤寒携带者与急性感染病例中的癌症风险.
主要方法:
- 一项回顾性研究分析了慢性伤寒和偏伤寒携带者的癌症风险.
- 与来自特定疫情的急性伤寒感染个体的对照组进行比较.
主要成果:
- 慢性伤寒携带者显示,胆囊癌的风险显著增加 (观察/预期病例:167.0).
- 还观察到胰腺 (8.1),结直肠 (3.0),肺 (2.5) 癌症和整体瘤 (2.6) 的风险增加.
- 在急性伤寒感染的个体中没有发现类似的癌症风险过剩.
结论:
- 长期的伤寒携带,而不是急性感染,被确定为各种癌症,特别是胆囊癌的重要危险因素.
- 通过抗生素或胆囊切除术消除慢性伤寒载体对于预防癌症至关重要.
- 对于公共卫生倡议来说,对慢性载体的准确记录是必不可少的.
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