转化区大循环切除的有效性和安全性
A Bigrigg1, D K Haffenden, A L Sheehan
1University Department of Obstetrics and Gynaecology, Southmead Hospital, Bristol, UK.
Lancet (London, England)
|January 1, 1994
概括
转化区大循环切除术 (LLETZ) 是对宫内皮质瘤 (CIN) 的安全有效治疗方法. 随访显示复发率低,对生育能力或月经没有负面影响.
科学领域:
- 妇科 妇科医生 妇科
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 宫内皮质瘤 (CIN) 是宫的癌前疾病.
- 转化区的大循环切除 (LLETZ) 是CIN的常见治疗方法.
- 此前,LLETZ的长期有效性和安全性数据有限.
研究的目的:
- 评估LLETZ在治疗CIN.的长期有效性和安全性.
- 评估LLETZ之后的复发率和残留损伤率.
- 调查LLETZ对女性生育能力和月经症状的影响.
主要方法:
- 1990年的一项研究跟踪了1000名接受LLETZ治疗的妇女.
- 宫细胞学被用于超过2年的随访.
- 一个调查问卷评估了LLETZ3年后250名妇女的生育能力和月经症状,与对照组相比较.
主要成果:
- 复发率和残留病变率在第一年为5.0%,第二年为0.6%.
- 作为重复手术,LLETZ是有效的,尽管负性组织学率较高 (20%与4.7%相比).
- 在LLETZ患者和对照人群之间,没有发现生育能力或月经症状的显著差异.
结论:
- 对于长期复发率较低的CIN,LLETZ是一种安全有效的治疗方法.
- 这种程序似乎不会对女性的生育能力或月经周期产生负面影响.
- 对于持久或复发性CIN,LLETZ可以安全地作为重复程序使用.
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