爱斯坦-巴尔病毒的持续性和与病毒相关的瘤
1Department of Pathology, University of Birmingham, Edgbaston, UK.
Lancet (London, England)
|February 5, 1994
概括
爱斯坦-巴尔病毒 (EBV) 主要感染B淋巴细胞以持久性,挑战以前的理论. 表皮细胞感染是次要的,并不是EBV持久性的关键,尽管对某些癌症有意义.
科学领域:
- 病毒学 病毒学
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 爱斯坦-巴尔病毒 (EBV) 与淋巴细胞和上皮细胞癌症有关.
- 之前的假设表明,口腔上皮质对于初级EBV感染和持续性至关重要.
研究的目的:
- 重新评估埃普斯坦-巴尔病毒 (EBV) 感染和持久性的主要部位.
- 澄清B淋巴细胞和上皮细胞在EBV持久性和相关恶性瘤中的作用.
主要方法:
- 对EBV感染动态的当前证据的审查和综合.
- 关于EBV热带性和持久性的体外和体内研究的分析.
主要成果:
- 有证据表明,初级EBV感染和持久性是由B淋巴细胞介导的.
- 隐性上皮细胞感染似乎与EBV持久性相关,但与癌症的发展有关.
结论:
- 由B淋巴细胞介导的途径被认为是EBV持久性的主要途径.
- 需要进一步的研究来了解T细胞参与和EBV在致癌中的作用.
相关概念视频
Mechanisms of Retrovirus-induced Cancers
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Mechanisms of Retrovirus-induced Cancers
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Immunological Memory
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature is...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature is...
Cytomegalovirus Disease
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...


