艾滋病毒在淋巴系统之外的再分配与艾滋病的发病
Y K Donaldson1, J E Bell, J W Ironside
1Department of Medical Microbiology, University of Edinburgh, UK.
Lancet (London, England)
|February 12, 1994
概括
人类免疫缺陷病毒 (HIV) 直接感染广泛影响获得性免疫缺陷综合征 (AIDS) 患者的器官. 艾滋病毒在免疫系统之外传播是一种晚期的事件,对免疫抑制水平敏感.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 获得性免疫缺陷综合征 (艾滋病) 症状的发病因子尚未完全理解.
- 人类免疫缺陷病毒 (HIV) 直接感染在艾滋病表现中的作用需要进一步调查.
研究的目的:
- 量化各种器官中直接艾滋病毒感染的程度.
- 为了将艾滋病毒组织分布与艾滋病患者的疾病严重程度和病理变化相关联.
主要方法:
- 使用定量聚合酶链反应 (PCR) 检测和测量HIVDNA.
- 分析了来自多个器官 (大脑,肺,结肠,肝脏,脏,淋巴结,周围血液) 的组织样本.
- 进行了组织病理检查.
主要成果:
- 在艾滋病患者的器官中检测到广泛的HIV感染 (CDC类IV),包括大脑,肺,结肠和肝脏.
- 没有艾滋病相关疾病的HIV阳性个体 (CDCII类) 没有显著的非淋巴细胞器官感染.
- 在这两组人群中,在脏,淋巴结和周围血液细胞中始终发现高水平的艾滋病毒.
- 特定的病理发现,如巨细胞脑炎,与大脑组织中的高HIV负载相关.
结论:
- 直接感染非淋巴细胞器官的HIV感染是艾滋病病原发生的晚期事件.
- 艾滋病毒在免疫系统之外的传播高度依赖于患者的免疫抑制程度.
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