破碎的和鸟在Drosophila的无翼信号通路中起作用
J Noordermeer1, J Klingensmith, N Perrimon
1Howard Hughes Medical Institute, California.
Nature
|January 6, 1994
概括
在Drosophila中无翼信号传递涉及细分极性基因. 这项研究表明,无翼动物通过乱的和鸟来调节化的基因表达和皮肤的发育.
科学领域:
- 发展生物学 发展生物学
- 分子遗传学 分子遗传学
- 细胞信号传递 细胞信号传递
背景情况:
- Wnt基因编码分泌的蛋白质对于发育和癌症至关重要.
- 没有完全理解Wnt信号传导路径.
- 德洛索菲拉无翼基因是Wnt家族的一位特征很好的成员.
研究的目的:
- 为了调查细分极性基因是否调解无翼信号.
- 为了阐明无翼信号传递的分子机制.
主要方法:
- 使用一种可诱导热冲击的无翼转基因.
- 在Drosophila进行了基因表观试验.
- 分析了基因表达和皮质分化.
主要成果:
- 证明无翼信号是由分段极性基因调解的.
- 展示了无翼的行为通过乱和.
- 证实了对homeobox基因和皮质分化的影响.
结论:
- 无翼的信号通路中的关键组成部分是的和的.
- 无翼信号调节下游基因表达和发育过程,如皮质形成.
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