婴儿时期的炎症性肠病和家庭卫生
A E Gent1, M D Hellier, R H Grace
1Salisbury District Hospital, Odstock, Wiltshire, UK.
Lancet (London, England)
|March 26, 1994
概括
克罗恩病可能与早期生活中接触现代卫生设施有关. 这项研究发现克罗恩氏病与婴儿时使用热水龙头和单独的浴室之间存在关联.
科学领域:
- 胃肠病学 胃肠病学
- 流行病学 流行病学
- 环境健康 环境健康
背景情况:
- 在过去的50年里,克罗恩病的发病率在发达国家显著上升.
- 克罗恩病的确切原因尚不清楚,假设包括遗传倾向和环境因素.
- 延迟暴露于肠道感染被认为是克罗恩病的潜在触发因素.
研究的目的:
- 调查早期生活家庭设施与克罗恩病发展之间的关联.
- 区分克罗恩病的环境风险因素与性结肠炎的环境风险因素.
- 探索现代卫生条件影响克罗恩病病因的假设.
主要方法:
- 采用了一种病例控制研究设计.
- 133名被诊断患有克罗恩病的患者和231名性结肠炎的患者进行了比较.
- 对照组从一般人群中选择,并根据年龄和性别进行匹配.
主要成果:
- 克罗恩病病例在他们的第一个家里有更大的热水龙头 (几率比率5.0,95% CI 1.4-17.3).
- 患有克罗恩病的受试者在他们的第一个住所中拥有单独的浴室的患病率也更高 (几率比率为3.3,1.3-8.3).
- 在性结肠炎和早期生活家庭设施之间没有明确的关联.
结论:
- 早期接触现代卫生设施,即热水龙头和单独的浴室,可能是克罗恩病的危险因素.
- 这些发现表明,过去50年来卫生和卫生习惯的变化可能导致克罗恩病的发病率上升.
- 需要进一步的研究来阐明将卫生设施与克罗恩病病原体联系在一起的机制.
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