克拉德里宾用于治疗慢性渐进性多发性硬化症
J C Sipe1, J S Romine, J A Koziol
1Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, California 92037.
Lancet (London, England)
|July 2, 1994
概括
免疫抑制药物cladribine通过稳定神经学分数和减少脱髓化,有利地影响慢性渐进性多发性硬化症 (MS). 这项研究发现,克拉迪宾对于MS患者来说是一种安全有效的治疗选择.
科学领域:
- 神经免疫学 神经免疫学
- 临床药理学 临床药理学
背景情况:
- 多发性硬化症 (MS) 是一种慢性,渐进和致残的脱髓化疾病.
- 据信自身免疫过程在MS的发病过程中起着重要作用.
研究的目的:
- 评估核酸药物克拉迪宾在患有慢性进展性多发性硬化症的患者中的疗效和安全性.
- 评估克拉迪宾对神经状态,脱髓化和脑脊液标记物的影响.
主要方法:
- 一个随机的双盲试验,涉及51名慢性进展性MS患者.
- 患者接受了四个月一次的克拉迪宾 (0.7毫克/千克) 或安慰剂疗程,通过中央线路给药.
- 神经学评估,脑脊髓液分析和脑磁共振成像 (MRI) 在12个月内定期进行.
主要成果:
- 与安慰剂组相比,用克拉迪宾治疗的患者在MRI上表现出稳定或改善的神经学得分,并减少了脱髓化体积.
- 大脑脊髓液的基基隆带度在克拉迪布林组中也稳定或改善.
- 克拉迪宾一般耐受性很好,只有一个显著毒性病例 (骨髓抑制).
结论:
- 免疫抑制药物cladribine有利地影响慢性渐进性多发性硬化症的过程.
- 克拉德里宾在稳定疾病进展方面表现出有效性,并且通常耐受良好.
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