周围产生的麻疹感染和随后的克罗恩病
A Ekbom1, A J Wakefield, M Zack
1Cancer Epidemiology Unit, University Hospital, Uppsala, Sweden.
Lancet (London, England)
|August 20, 1994
概括
婴儿时期接触麻疹病毒可能会增加克罗恩病的风险. 这项研究发现,在麻疹流行期间出生的人群中,克罗恩病的病例更多,这表明存在联系.
科学领域:
- 流行病学 流行病学
- 病毒学 病毒学
- 胃肠病学 胃肠病学
背景情况:
- 克罗恩病的病因仍然是未知的.
- 麻疹病毒被认为是潜在的促成因素,特别是在生命早期暴露时.
- 以前的研究表明,麻疹流行病与克罗恩氏病发病率增加之间存在相关性.
研究的目的:
- 调查麻疹流行病与克罗恩病发病率之间的关联.
- 为了确定在麻疹流行期间的分娩是否会增加患克罗恩病的风险.
- 评估围产期对麻疹暴露与克罗恩病相关的脆弱性.
主要方法:
- 在瑞典四个县 (1945-1954) 鉴定了在30岁之前被诊断患有克罗恩病的个人.
- 分析了研究期间的麻疹流行病数据和出生记录.
- 计算了预期与观察到的克罗恩病和性结肠炎病例,这些病例是在麻疹流行高峰后的3个月内出生,并调整为活产.
主要成果:
- 在麻疹流行病峰值 (SIR 1.46) 之后出生的人群中,发现克罗恩病病例的显著过剩 (57例观察到与预期的39.0例).
- 观察到的性结肠炎病例数量 (42) 与预期的病例数量 (46.8) 相似.
- 结果表明,麻疹流行病与随后的克罗恩病诊断之间存在统计学上显著的关联.
结论:
- 这些发现加强了将麻疹病毒与克罗恩病联系在一起的假设.
- 周产期似乎是一个关键的窗口的脆弱性,麻疹暴露有关克罗恩氏病的发展.
- 需要进一步的研究来阐明这种关联所涉及的具体机制.
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