吸烟和小腹主动脉动脉瘤的增长速度
S T MacSweeney1, M Ellis, P C Worrell
1Department of Surgery, Charing Cross and Westminster Medical School, London, UK.
Lancet (London, England)
|September 3, 1994
概括
吸烟会加速腹腔大动脉动脉瘤的生长. 戒烟可以显著减缓小动脉瘤的扩张速度,可能防止需要手术.
科学领域:
- 血管外科 血管外科
- 心血管医学 心血管医学
- 公共卫生 公共卫生
背景情况:
- 吸烟是腹腔大动脉动脉瘤 (AAA) 的主要危险因素.
- 早期干预以限制AAA生长对于防止手术修复至关重要.
- 小AAA需要监测以了解它们的进展.
研究的目的:
- 为了研究吸烟对小腹主动脉动脉瘤生长率的影响.
- 为了确定戒烟是否影响AAA扩张.
- 为了将AAA增长与吸烟强度相关联.
主要方法:
- 在3年内对43名患有小AAA的患者进行了连续超声波评估.
- 当前吸烟者与非吸烟者之间动脉瘤生长率的比较.
- 测量血清丁水平以量化吸烟暴露.
主要成果:
- 中位数AAA扩张率为0.13厘米/年.
- 继续吸烟的患者 (0.16厘米/年) 与戒烟的患者 (0.09厘米/年) 相比,观察到显著更高的生长率,p=0.038.
- AAA的增长速度与血清丁氨酸度正相关.
结论:
- 戒烟与小腹主动脉动脉瘤的增长率降低有关.
- 监测AAA的进展和建议戒烟是重要的临床策略.
- 进一步的研究可以探索缓解吸烟者AAA扩张的干预措施.
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