在患有单血管冠状动脉疾病的患者中,随着氧气消耗增加, perfusion 反应的总体变化
G Sambuceti1, P Marzullo, A Giorgetti
1CNR Institute of Clinical Physiology, Pisa, Italy.
Circulation
|October 1, 1994
概括
冠状动脉疾病 (CAD) 患者表现出异常的心肌血流 (MBF) 调节,即使在有正常动脉的区域. 这项研究揭示了MBF对CAD中代谢需求增加的反应受损,这表明除表心狭窄外的因素影响冠状动脉储备.
科学领域:
- 心脏病学 心脏病学
- 心血管生理学心血管生理学
- 医疗成像医学成像
背景情况:
- 冠状动脉疾病 (CAD) 与显然正常的冠状动脉区域中心肌血流 (MBF) 的异常调节有关.
- 这种改变的MBF调节与对CAD中代谢需求增加的反应之间的关系尚不清楚.
研究的目的:
- 为了研究心肌动脉血流 (MBF) 对冠状动脉疾病 (CAD) 患者增加代谢需求的反应.
- 为了比较正常供应和CAD患者的后静脉区域的MBF调节与健康受试者.
主要方法:
- 使用正子发射断层扫描 ([13N]氨) 对9名正常受试者和24名CAD患者进行心肌动脉血流 (MBF) 评估.
- 测量是在静止状态下,在心房节奏低心率期间,在二皮里达摩尔注射后进行的.
- 在CAD患者中,MBF被评估为后静脉 (S) 和正常供应 (N) 区域.
主要成果:
- 与正常人相比,CAD患者在S和N地区的MBF显著降低,相比之下,在休息状态下,在节奏中和经过二皮里达摩尔后的正常受试者.
- 虽然正常受试者在MBF变化和速压产物之间显示出强烈的相关性,但这种相关性在CAD患者的S和N区域都不存在.
- 这些发现表明,无论心上狭窄的严重程度如何,在CAD中流量调节受损.
结论:
- 除表心狭窄之外的因素显著影响CAD患者对增加的代谢需求和冠状动脉储备的流量反应.
- 在MBF调节中存在异常,即使在没有显著狭窄的冠状动脉段中也是如此.
- 需要进一步的研究来确定影响CAD冠状动脉流量储量的这些额外因素.
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