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在Drosophila的表皮中,无翼信号需要口

J P Couso1, A Martinez Arias

  • 1Department of Zoology, University of Cambridge, England.

Cell
|October 21, 1994
PubMed
概括

诺奇 (N) 基因的突变影响了多索菲拉的发育. 新发现表明,无翼 (wg) 基因产物作为Notch蛋白的配体,影响发育过程.

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Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...