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Updated: Jul 30, 2026

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在mGluR1突变小鼠中缺陷小脑长期抑郁和运动学习受损

A Aiba1, M Kano, C Chen

  • 1Howard Hughes Medical Institute, Center for Learning and Memory, Cambridge, Massachusetts.

Cell
|October 21, 1994
PubMed
概括

甲基氨酸受体1 (mGluR1) 对于小脑长期抑郁症 (LTD) 是至关重要的. 它在突变小鼠中的缺陷会导致心力衰竭和眼条件受损,主要是由于受损的LTD.

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Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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