延迟型过敏症,菌根疫苗和保护性免疫.
P E Fine1, J A Sterne, J M Pönnighaus
1Department of Epidemiology and Population Sciences, London School of Hygiene and Tropical Medicine, UK.
Lancet (London, England)
|November 5, 1994
概括
对菌根细菌抗原的延迟型过敏性提供了对麻风的保护,但不是结核病的保护. 低级敏感性可能表明环境暴露和保护,而持续的疫苗诱导过敏性与BCG疫苗疗效无关.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 疫苗学 疫苗学 疫苗学
背景情况:
- 延迟型过敏在对菌根菌感染的免疫力中的作用仍在争论中.
- 了解疫苗诱导免疫的相关性对于改善BCG等疫苗至关重要.
- 在不同人群中,BCG疫苗的有效性有很大差异.
研究的目的:
- 调查延迟型过敏对抗结核病和麻风病的保护的影响.
- 为了确定疫苗诱导的对抗菌根病的保护性免疫的相关物质.
- 为了澄清过敏和BCG疫苗有效性之间的关系.
主要方法:
- 这是一项大规模的前性研究,涉及马拉维超过7万名个人.
- 用菌根细菌抗原 (结核素和麻风细菌抗原) 进行皮肤检测.
- 结核病和麻风病发病率的五年随访,分析了因共变量而调整的发病率比率.
主要成果:
- 接种BCG疫苗可以预防麻风,而不依赖于延迟型过敏.
- 在未接种疫苗的个体中,对菌根细菌抗原的过敏与强有力的预防麻风有关.
- 在结核素过敏度和结核病发病率之间观察到J形关系,低度敏感度与最低发病率相关.
结论:
- 延迟型过敏对结核病和麻风有不同的影响.
- 低水平的过敏,可能来自环境菌根菌,与保护有关.
- 持续的疫苗诱导过敏症不是BCG诱导的对菌根菌病的保护的可靠相关值.
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